Browsing by Author "Trembleau, Laurent"

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    • Discovery and Biosynthetic Investigation of a New Antibacterial Dehydrated Non‐Ribosomal Tripeptide 

      Wang, Shan; Fang, Qing; Lu, Zhou; Gao, Yingli; Trembleau, Laurent; Ebel, Rainer; Andersen, Jeanette Hammer; Philips, Carol; Law, Samantha; Deng, Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)
      Dehydroalanine (Dha) and dehydrobutyrine (Dhb) display considerable flexibility in a variety of chemical and biological reactions. Natural products containing Dha and/or Dhb residues are often found to display diverse biological activities. While the (Z) geometry is predominant in nature, only a handful of metabolites containing (E)‐Dhb have been found thus far. Here we report discovery of a new ...

    • Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria 

      Tadesse, Margey; Svenson, Johan; Sepcič, Kristina; Trembleau, Laurent; Engqvist, Stig Olov Magnus; Andersen, Jeanette Hammer; Jaspars, Marcel; Stensvåg, Klara; Haug, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-02-14)
      Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian <i>Synoicum pulmonaria</i> collected off the Norwegian coast. The structures of natural pulmonarins A and B were tentatively elucidated by spectroscopic methods and later verified by comparison with synthetically prepared material. Both pulmonarins A ...